Single-Cell Lineage Tracing

Third-cycle level | 1.5 credits (HEC) | Course code: C5F6061
HT 2025
Study period: 2025-10-20 - 2025-10-24
LANGUAGE OF INSTRUCTION: The course is given in English
Application period: 2025-04-15 - 2025-05-06
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Course description

The course aims to offer participants an understanding about lineage tracing approaches to map the developmental history of cells within a tissue. This knowledge provides fundamental insights into normal tissue development and diseases such as cancer. We cover most recent methods that allow combined lineage tracing and single-cell transcriptomics for detailed comparisons between molecular and developmental histories.

This course introduces the foundational concepts of various single-cell lineage tracing approaches, covering their experimental implementation, computational analysis, and data interpretation. Featuring renowned international speakers who have made pioneering contributions to method development and biological discovery, the course also provides ample opportunities for students to engage with experts and discuss topics relevant to their own research.

Prerequisites and Selection

Prerequisite courses, or equivalent

No prerequisite courses, or equivalent, demanded for this course. 

Selection

Selection will be based on:  
1) the relevance of the course syllabus for the applicant’s individual study plan/research (according to written motivation). 
2) start date of doctoral studies (priority given to earlier start date). 

Course director

Michael Ratz

Course syllabus

C5F6061

Department

Department of Cell and Molecular Biology

Doctoral programme

Cell Biology and Genetics (CBG)

Type of course

**Other course

Keywords

lineage tracing, single-cell rna-seq, development, stem cells, barcoding

CONTACTMichael Ratz

michael.ratz@ki.se