Tumor Evolution in Space and Time

Third-cycle level | 1.5 credits (HEC) | Course code: K7F6067
HT 2025
Study period: 2025-11-03 - 2025-11-07
LANGUAGE OF INSTRUCTION: The course is given in English
Application period: 2025-04-15 - 2025-05-06
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Course description

This course provides an in-depth exploration of tumor evolution across both spatial and temporal scales. By examining the genetic, epigenetic, and microenvironmental factors that together drive tumorigenesis and metastasis, students will develop an understanding of how tumors evolve over time, within individuals and across tissues. The course gives a comprehensive overview of the key methodologies used to study tumor evolution, including single-cell sequencing, organoid systems, and spatial transcriptomics. Students will also explore the role of the tumor microenvironment in shaping cancer progression and therapeutic resistance and discuss clinically relevant aspects of tumor evolution and metastases with clinicians.

In this five-day course, students will engage in lectures and interactive workshops led by experts in the fields of cancer biology, tumor evolution, spatial transcriptomics, and single-cell sequencing. Clinical placements to attend metastases surgery, the oncologic outpatient unit or cancer pathology will be offered as an optional choice for students of this course.

Prerequisites and Selection

Prerequisite courses, or equivalent

Students should have acquired a foundational understanding of cancer biology, such as by completing the Basic Course in Tumor Biology and Oncology or its equivalent.

Selection

Selection will be based on:  
1) the relevance of the course syllabus for the applicant’s individual study plan/research (according to written motivation). 
2) start date of doctoral studies (priority given to earlier start date). 

 

Course director

Course coordinator:
Kasper Karlsson, Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, kasper.karlsson@ki.se

Additional course leaders:
Arne Östman, arne.ostman@ki.se
Maria Kasper, maria.kasper@ki.se
Ninib Baryawno, n.baryawno@ki.se
Marco Gerling, marco.gerling@ki.se
Camilla Engblom, camilla.engblom@ki.se

Course syllabus

K7F6067

Department

Department of Oncology-Pathology

Doctoral programme

Tumour Biology and Oncology (FoTO)

Type of course

**Other course

Keywords

Tumor Evolution, Tumor microenvironment, Tumor heterogeneity

CONTACTKasper Karlsson

kasper.karlsson@ki.se