Course description
This course provides an in-depth exploration of tumor evolution across both spatial and temporal scales. By examining the genetic, epigenetic, and microenvironmental factors that together drive tumorigenesis and metastasis, students will develop an understanding of how tumors evolve over time, within individuals and across tissues. The course gives a comprehensive overview of the key methodologies used to study tumor evolution, including single-cell sequencing, organoid systems, and spatial transcriptomics. Students will also explore the role of the tumor microenvironment in shaping cancer progression and therapeutic resistance and discuss clinically relevant aspects of tumor evolution and metastases with clinicians.
In this five-day course, students will engage in lectures and interactive workshops led by experts in the fields of cancer biology, tumor evolution, spatial transcriptomics, and single-cell sequencing. Clinical placements to attend metastases surgery, the oncologic outpatient unit or cancer pathology will be offered as an optional choice for students of this course.
Prerequisites and Selection
Prerequisite courses, or equivalent
Students should have acquired a foundational understanding of cancer biology, such as by completing the Basic Course in Tumor Biology and Oncology or its equivalent.
Selection
Selection will be based on:
1) the relevance of the course syllabus for the applicant’s individual study plan/research (according to written motivation).
2) start date of doctoral studies (priority given to earlier start date).
Course director
Course coordinator:
Kasper Karlsson, Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, kasper.karlsson@ki.se
Additional course leaders:
Arne Östman, arne.ostman@ki.se
Maria Kasper, maria.kasper@ki.se
Ninib Baryawno, n.baryawno@ki.se
Marco Gerling, marco.gerling@ki.se
Camilla Engblom, camilla.engblom@ki.se
Course syllabus
K7F6067
Department
Department of Oncology-Pathology
Doctoral programme
Tumour Biology and Oncology (FoTO)
Type of course
**Other course
Keywords
Tumor Evolution, Tumor microenvironment, Tumor heterogeneity