Epigenetics and its Applications in Clinical Research

Third-cycle level | 1.5 credits (HEC) | Course code: K8F2601

Course description

If you want to discover epigenetics and it's application in clinical research, join this course!

The start of the course brings you up to speed with an overview of basic epigenetic mechanisms (DNA methylation, histonemodifications, non-coding RNAs and chromatin organization).

We will also covers the main methodologies used to study epigenetics such as methods used to detect and quantify DNA methylation, chromatin immunoprecipitation and conformation capture, next generation sequencing and we'll emphasize on basic bioinformatic considerations and tools for epigenetic analysese.

These lectures will be intertwined with talks from local and international speakers focusing on key epigenetic mechanisms in health and disease (cancer, inflammation, metabolic disorders etc). Current applications of epigenetic research in common diseases, and future perspectives will also be discussed.

Prerequisites and Selection

Prerequisite courses, or equivalent

No prerequisite courses, or equivalent, demanded for this course.  

Selection

Selection will be based on:  
1) the relevance of the course syllabus for the applicant’s individual study plan/research (according to written motivation). 
2) start date of doctoral studies (priority given to earlier start date). 

Course director

Lara Kular

Majid Pahlevan Kakhki

Maria Needhamsen

Course syllabus

K8F2601

Department

Department of Clinical Neuroscience

Doctoral programme

Cell Biology and Genetics (CBG)

Type of course

**Other course

Keywords

Epigenetics, DNA methylation, non-coding RNAs, Histone modifications, Epigenetic editing tools, Epigenetics ageing, Bioinformatics, clinical translation

CONTACTLara Kular

lara.kular@ki.se